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In theory, it could

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[DOI] [PMC free article] [PubMed] [Google Scholar] Yan QS, Yan SE (2001) Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study

Moreover, 6 week exposure to CUMS showed further GABA level reductions in tissues such as hippocampus, blood and feces, suggesting that more widespread neurotransmitter depletion may be stress type and duration dependant (Jia et al., 2024)

That said, smaller individuals may do well with lower daily doses (e.g